bill andrews to you. bill is thepresident of sierra sciences. he's an award-winning microbiologist whodiscovered the enzyme telomerase and you'll hear why this is one of thebiggest medical breakthroughs of all time a little later during this webinar.he's called the man who would stop time by popular science magazine and he's namedin over 50 us patents which is unheard
anti aging home, of for any biologist. he's created the world's strongest telomerase inducer ever which you'll be hearing a lot more about as well too.and he really is leading the way in the fight against aging and all age-relateddiseases. and also i'd like to welcome
katherine kennard who's anaward-winning actress for television and theatre roles. she's well known for her tvroles in underbelly and spartacus, nothing trivial, shortland street andmany many more. she's a wonderful animal rights activists. she supports at-riskchildren and young struggling mothers. and we're delighted that she isrecognized now as the face of one truth 818. hi katherine. for those of you who don'tknow me i'm rachael d'aguiar sanders. i'm the director of chase life extensionfoundation and we provide funding for research into curing aging and we'realso the creators of the one truth 818 range which i have formulated foreverybody 818 serum and i am
your host for today. first thing, to all of our guests out there,thank you for the questions that you have already posted ahead of time, it wasgreat to see your enthusiasm's there. and we're going to be answering some ofthose pre posted questions during the interviews that i do with our guestshere. anything you post during the webinar, we will do our best to answer every single one of them afterwards so just under your video screen whereyou're seeing me right now, that's where you can post some questions as they pop into your mind and we will answer them afterwards.
now the science and breakthroughs thatwe are about to discover on this call are amazing to all of humankind, butthey're also really applicable to people who own anti aging skin care and beautybusinesses to be right at the forefront of all of this technology. so if you have one of those businessesplease stay with us until the end because we will have a very specialoffer that we can reveal to you at the end of this webinar. so previously, take a breath that was quite anintroduction for everybody. bill, could you
start please by giving us just a basicand an outline of what telomeres are. well, let me begin with simply saying that a lot of peoplebelieve that we all age the same way as old trucks sitting in a field age, you know. they think we age because of thethe exposure to the sun, the wind, the rain, etc. but we're not like oldtrucks sitting in a field. we actually have cells in our skin that can divide.so when we get a sunburn and we kill cells in our skin, other cells can divideto replace those cells. and so the question is why do we age
if we don't have the same kind ofproblems as an old truck sitting in a field. well it turns out it was discovered inthe 1960s that human cells actually can't continue to divide up forever. they actually have a limit to how manytimes they can divide and i like to think of it like every time a celldivides it like takes a ride ticket, you know like a ticket off a roll of tickets forrides at the amusement park. let's say okay so it's like they're given acertain amount of tickets every time they divide, they take the ticket away andeventually they run out of tickets and
the cells can no longer divide afterthat. and it turns out that we have now discovered that those ride tickets areactually found at the very tips of our chromosomes. and so every cell in ourbody is given a certain number of ride tickets and every time the cells divideit loses a ride ticket and when they get down to essentially zero ridetickets, they can't divide any more and actually when they start to get downto just a few ride tickets they, our cells lose the ability to even do a lot ofdifferent functions. so it's appearing that that's now how we age andwe know this from studies where we
figured out how to add more ridetickets back or essentially lengthen the telomeres. so if you think about a human ismade up of cells. our skin is made up of our cells but so is the rest of us, we areessentially mostly cells and cells are really microscopic little things whenyou zoom in you can see cells in the microscope and then inside the cells there's the nuclei and inside the nucleiare found our chromosomes and at the tips the chromosomes is where thesetelomeres are. the chromosomes are where our genes are that gives us our haircolor, eye color. all that kind of stuff.
but now, the very tips of thesechromosomes that the telomeres we have noticed since like the nineteenseventies that they get shorter as you age. this is because they're losing theseride tickets as i'd mentioned. and it got so studied, people, scientistsall over the world was studying so much that we started finding out thatpeople can actually measure the length of telomeres and tell somebody how oldthey are. more importantly they can tell them how old, how long it will be beforethey die of old age. so the telomeres started becomingsomething that was considered really
important but people weren't reallyclear whether this was a result of aging or actually cause of aging and that waswhere i got involved. so the telomeres are at the very tips ofour chromosomes and i ended up discovering an enzyme that wouldlengthen them called telomerase. but simply i can talk more about it later,but simply that's the basics of what it is. we have essentially aclock of aging that's ticking and it's found at thetips of all of our chromosomes and they're called telomeres. great thank you, bill and i think that's a reallygreat a recap for anyone who has heard
of telomere biology before but alsofor those who have never heard of it, he was the perfect person to hear itstraight from, straight from the and the man himself. bill, anyone in the field ofanti aging knows how well respected you are and that you know exactly whatyou're talking about but you're not the only person who has been proving theseconcepts in the scientific world. are you able to share with others some of the proofs of concept that someof your colleagues and people around the
world have also be doing to corroboratewhat you're saying about telomeres being you know, ... what other proofs of concept on that, bill? well let's first start with my lab wheni was still working at a company called geron corporation. we discovered, you know, the thing was that we saw the telomere shortening in every cell the body, butexcept, the only exception was our reproductive cells. our reproductivecells, when those cells divided they weren't essentially losing ridetickets, their telomeres weren't getting
shorter. ah and so was during my research therewith a team of scientists that we discovered that our reproductive cellsproduce an enzyme called telomerase and telomerase actually adds ride ticketsback or lengthens telomeres. so what we did is we then started taking this telomerase enzyme and start putting itinto other cells of the body like skin cells growing in a petri dish. and wewere able to demonstrate that these cells not only stop losing the ridetickets or telomeres stop getting shorter, they actually got a lot longer and by everymeasure of, method of measurement
that the cells got younger, looking atall the different genes, they are affected by that, and have been shown in lots of studies to be biomarkers of aging, we saw that all these genes reversed tobeing the young type of genes. and so by every, as i said method ofmeasurement that we can imagine, the cells got younger just by lengtheningthe telomeres. well that was the first i say proof of concept that telomere shortening wasn't a result of aging, it was actually the cause of aging. and so then scientists, including scientists working with me, well that one, just about when i wasleaving geron to start my own company,
uh, they grew human skin on the back of amouse and uh demonstrated that when they lengthen the telomeres there, the skin got younger by every method ofmeasurement. so not only have we shown that human cells in a petri dish got younger, but even skin, uh let's say a tissue on an anotheranimal got younger. now that all this work was done in uh another company. but it goteven better when when people like dr. ron de pinho bred mice that hecould turn the telomerase gene on and off inside of all their cells and he wasable to show that when he produced
telomerase in the cells of really old mice, these mice got young in every way imaginable. these mice they were so old theycould barely walk around. their hair was getting, turning gray, their hairwas falling out. they couldn't reproduce, their brainswere deteriorating, they couldn't remember how to go through a maze thatthey used to be able to go through. organs were getting smaller, their senseof smell was disappearing, there was a whole bunch of different things that werelooked at. and when they lengthened these telomeres, these really old mice became young in every way imaginable.
they could breed again, they couldremember how to do things, their sense of smell came back. their hair came back, everything looked like young and they acted like young mice in every way. andnow this has recently been repeated by another lab in spain headed up by dr. maria blasco. and i mean i'd like to be able tosay that these things are available for humans right now, but they requiredsome pretty drastic techniques of gene therapy that really we wouldn't want to do on humans yet. but the, uh you
know, hopefully in the near future wewill have ways to do this that will work really effectively on humans.but those are the proof of concepts that i've just mentioned and i'm justlooking forward to the day when we can actually treat a human and see thesame kind of results. great you've actually, you answeredkaren sinclair's questions which was whether or not this technology would beapplicable for every cell in the body. and what you've just explained to us isthat if these are affecting cells and if you're affecting one, you're actuallyaffecting all of them and that when these technologies do move to humans wecould have the expectation like ron de
pinho proved with the mice thatevery representation of an age market biologically would be reversed is that correct?yes, and for the moment when we're talking aboutthe skin cream uh we're talking because its skin cream only because it'sactually been approved for use whereas other things eventually thisthis chemical that's in the skin cream will be approved for use in other waystoo, but right now it's approved just for skin. ok so this chemical that you mentioned inthe skin cream is the furthest that your lab has gotten with technology to bereducing age in humans, tam-818. would you tell us a littlebit about that please, bill? well we've
been, we've been doing this researchsince 1999 developing different assays high-throughput drug screening whichallows us to test thousands of chemicals a day and we've been looking at this fora long time that we've we've tested like probably close to 400,000 differentchemicals a lot of them were just random but even but many of them were intentionallydesigned by us to increase potency and stuff. but in let's say 2008, 2007probably, we discovered our very first chemical that would induce telomeraseand that allowed us to, and when i say induced telomerase what i'm saying isthat every cell in our body has a gene
that's designed to produce telomerase sothat genes are like the the things that give us our hair color, eye color, thingslike that. well there is also a gene that is responsible for producing telomerase. and genes are controlled by like something like a light switch just liketurn your lights on and off in your room. so the gene is turned off in all of our cells and i could spend an hour explainingwhy that is, but it turns out it's it's nothing harmful at all. it's actually very healthy for usto turn it back on. and we found chemicals that would actually get in andturn that gene back on. and so we found
genes and then we found chemicals that would do this and we started designing new chemicals more and more. we first let's say we found things that were maybe .1% as strongas what we needed in order to reverse aging. then we found stronger stuff andthen stronger stuff and we finally got to one percent, then we got to two percent and we got to five percent and then our strongest so far is, we call it c0314818 because itwas a three hundred and fourteen thousand eight hundred and eighteenthchemical we tested and that that gives us about sixteen percent of thetelomerase activity that we think we need
to actually turn us all into 24 yearolds again. but it's but we're extrapolating we can see that we're onan upward trend and we could be there within a year. but unfortunately when we,right about the time we discovered c 0314818, the global financial crisis just wiped out investors' ability to invest in ourresearch anymore. and so it's been a struggle ever since andwe've been hanging in there. oh but one of the things that we're doing with thisc0314818 is we have licensed it to rachael's company clef and theymodified it further to improve safety and efficacy, etc.and they put it into the skin cream. and
as a result we're getting a royalty fromthe skin cream that is being used to fund our research to make more and more.so i'm, and i should qualify this point, i'm a scientist. i'm, i'm uh you know, i can do everythingabout science. i'm, i'm not really a marketer, that's rachael's department. i will tell youthat i do take, i do use one truth 818 myself every day twice a day because ibelieve in the science. the science is just unbelievably great. but in terms oftrying to describe more about the skin cream and stuff in the marketing andetc, i would have to turn it over to
rachael. yeah thanks bill. so that's really uhwhere mine and bill's stories connect. and just a quick little history ofthe c0314818 is that it actually sat in the cupboard for years so you'd think let's probably see where it'll go, in mindthinking well i've only heard about it at one truth in the last couple ofyears. it got popped in the cupboard because it was just deemed way tooexpensive to be useful for anything. and also at 16% the scientists atsierra sciences figured that it wouldn't be enough to show anything.
so the initial testing was done onhuman fibroblast skin cells and there was a kind of idea that this moleculewould be perfect for a skin cream but at the price and at 16% it wasliterally just put in the cupboard. well i was given the license for thismolecule and we played around with a little bit and i've been in the beauty industry forover 22 years now i've tried everything on my face and i'm going to tell youwithin three weeks of using this molecule on my skin i noticed a changeto the point where we decided to invest a quarter of a million dollars. i workedfor the cosmetic scientists and i
formulated the one truth 818 serum. andthen i sent it to abbott laboratories in italy to have it independentlytested which was really nerve-racking because independent means just there you have no idea what is going to comeback at you. and if they'd seen something bad, canthey say, hey it's just average. they'd say you like it or lump it really. so anywaythe results that we got back were phenomenal and stunning and i proudlysay that we surprised bill and the other scientists up at sierra because at the16%, what they were expecting to see was nothing that you know if katherineand i were, you know, if i were using
and katherine wasn't, in 10 years time, i would look like i had aged a lot less than katherine. but it was just going to beslowing down the rate of aging and that makes logical sense to us at the time.but what we were seeing was actual age reversal. and during the time it took toformulate it and send it up to italy to get it tested, a small research came backabout telemorase preferentially lengthening the critically shorttelomeres. so up until that point, mostscientists were really concerned around the average length of telomeres andthought that that was the best market to go by.
well this research came out and it proved that the critically short telomeres, the amount of critically shorttelomeres you've got is much more important than the average length ofyour telomeres. and that when you express or induce telomerase, its going topreferentially link in those shorter ones first. so that explains why at sixteenpercent we're actually seeing age reversal which was just awesome. so after independently testing it initaly on a hundred people that was amazing to get those results based onreal-world testing as well. i could see
it really clearly and in a very academicway explain all the ingredients to people and why it works but we alwaysask simple questions like will it do a, will it work on pigmentation, will it lift and firm my eyelids, you know all those other questions. ididn't really have an answer to them because i hadn't had that one-on-onekind of capability to talk to people. so we also ran a trial in new zealand withanother 40 people as well. now we got some great feedback from there and a lotof it you can see on the website if you could, you can see the before and theafters. what i didn't find out is for those 140 people not one of them had areaction to the product. so we went to
market and the first country that weactually launched in was about two and a half years ago now in australia. i had no idea if anybody would have anyreactions whatsoever to one truth 818. it was strengthening sensitive skinand it was really great for areas of broken capillaries and a list of things, they're great for sensitized skin. but nobody had a reaction to it. then we've spread around that if anyone ishaving a slight kind of irritation, it's from some of the plant ingredientsin there we assume because it's not a normal occurrence. so we got somereally great feedback from that. i
just have a question here, forgive me while i read it, but it isfor me. it's from donna jean sheerly and she says that she's using her one truth andhis skin is still needing moisturizing and she's surprised by that. donna jean, one truth 818 isactually a serum so it doesn't have any exclusive ingredients in there that are meant tostay sitting on the skin. a serum is just made to get instantly into that skin.and what we did when we took the molecule from sierra sciences and got alicense for that, we did further medicinal chemistry on it and then we also poppedinto a liposome so that we would get
really deep penetration into the skin ofit like his own. so all of the ingredients in the serumhydrate and flex barrier in the skin and it then help deliver the moleculedeeper into the skin. we don't have ingredients there that's meant to be left on top of your skin, so many people do find that they still need amoisturizer over top and and that's quite normal. the other question she asked is the more you use the better it is, is thatright? it isn't yes, my self and all of the trial participants that you'll see on
the website use it twice a day and weget those results twice a day. but if you're going to be using it moreoften you will be inducing telomerase more often and you will seeeven faster results. so if you're getting married in three days time, start lathering iton every 10 minutes. but other than that twice a day should be, should bejust fine. now i mentioned how great itwas to have people using it who we could interact with and learn more fromwhen it came to a marriage of this amazing science into a commercialproduct. and to that end i'd like to ask some questions of my great friendkatherine kennard who
about a year ago when we had bill cometo new zealand and we had a day full of media and i thought, gosh how am i goingto be interviewed and host it at the same time. so i asked my beautiful friend, actress katherine kennard, to come along and do that for us. so she heard the science from bill, i thinkabout seven times that day and very patiently absorbed it all in. and then wespoke afterwards and she said that i'd really, really like to be involved. the science is amazing and itticked a lot of other boxes for katherine as well too.
so katherine, can you just, talking aboutyour skin, you're sitting there looking absolutely stunning as always, you're probably asked by so manycompanies to represent their products, to endorse them, to be part of them, whatmade you say yes to one truth? well when you're asked to endorse any product, for me it's about, it's about about the owners of the product obviously, where it's coming from, the integrity behind the product tome is the most important thing. so i mean just look at rachael's face and bill, you're looking amazing. you know, i mean for me the proof isin the pudding you've got to
if somebody's asking me to endorse a skin product and and i'm looking, i just look at their skin and go okay well if youhave been using it for a while now and you know that's telling me everything.and looking at rachael and her husband chris and that was my first like wellsomething's gotta be, gotta be good in this product. you know fake ads. and so and then ofcourse then it's about putting it, using it on my own skin and trying it for awhile and and just to see because i've had enough of my own skin issuesthroughout my life and i'm my skin's the first to react to anything that itdoesn't like, whether it's organic or not
or you know natural or not. and so thatwas of course the non reaction which you were talking about earlier, rachael. for me it was like a number, you know aclear sign that we're on to a good thing as well. obviously this thing to bill, all thattime, on that day that we met, and yeah i mean the science behind it makes, makestotal sense to me. and yeah i mean it's when you listenyou're like it's kind of hard to initially to believe it but then then but then it is believable and it isit clearly is true because it clearly is making a difference and so i'm, i hundred percent believe in science, you know.
and that's important but it's not just, it's not just 818 as well, it's the blend of what's in the serum, it's not just that it has this the anti-aging it'salso how it feels on skin and all the other beautiful ingredients inside of it.and of course there's no animal testing which is very is a big thing for me and yes i mean i am supportive of ofnatural as much as possible natural products and i think this is, what is that, ninety-five percent above, more than 95 percent natural soyeah i mean there has to be a lot of boxes that get ticked for me to endorsesomething.
and so that's why all these boxes got ticked with this product. now katherine you mentioned that you had some sensitivities sowhat you, what has your experience of using one truth 818 serum been? well yes i mean over the last, in mytwenties and thirties, i actually had terrible skin and acne, i had rashes andi was working the film industry. so it was, it was a very delicate issue for me and having to go on screen and my skin not being good, you know, back in the nineties film wasn't hd, right. so youcould get away with covering with fairly heavy makeup. but now because everything's in hd
you can't get away with anything thatthe less makeup you wear the better. yes so your skin just has to be, you know,and the pressure to have good skin of course it's got worse and worse. so yes i had terrible, i had bad skin when i was younger and into, i thought you'dgrow out of it, but i didn't, that was, i was close to my forties and things werejust starting to settle down a little bit for me. i spent thousands ofdollars on products, high-end products and down to light, very natural, make it in your own home products you know, just to see what worked, you know what will work for me, and really really struggled. ispent so much money it's ridiculous.
but what i found straight away with one truth is it was like drinking a glass of water though and it still feels like after oneyear every time i put it on monday night it'slike i'm drinking my water. there's nothing, i don't feel sensitive at all and usually you can feel after a while you'll start getting a reaction and especially around the eyes for me. it's probably, what's amazing about this product isthat i don't have to have an eye serum, i don't have to have all these differentthings that as long as i got that and
yes a little bit of moisturizer on topif needed depending on the, depending on the time of the year obviously. this is what's amazing and my eyes especially give it away when it comes to sensitivity, my eyes would always show the little reactions you know. and this is where it's like yeah, thisproduct's just amazing. cool, thank you. and look just on thatnote, because obviously you know katherine's not the only person who's,you know, had the real world experience of it, but i just want to backtrackslightly to the italian independent
testing that we had done and simplybecause it affects something, everything that katherine has been saying as wellas the science that bill has said. and we went above and beyond you may have heardme mention that we had a hundred volunteers now when you're flicking through your fashion magazines, you actually read the little fine print on the bottom asi do of course, these percentages that these massive skincare companiesare painting around when you look at the little disclaimer down the bottom it willsay something like a 14 day trial on ten or more women and the claims they have been making are: this makes my skin feel
smoother. it's all emotion, none ofit is measurable or tangible. so the test that we had done because ididn't want anybody to be able to dispute the evidence that we were goingto be providing are all they were performed by doctors and the clinical, andthey're all measured and you can find those on our website. we don't try to hide anyof our proving evidence because we are a very proud of it and we standbehind it. so if you want to see more of theirevidence especially that are from one of those anti aging businesses thati spoke about before, this is going to be the point of difference for youfor one truth is that you can present
all of their clinical information. we canshow the measured amount that we have reduced wrinkles and induced collagen, bio elastin as well as all those before andafter shots. so do make sure that you have a lookat those. and thank you katherine for sharing your story. katherine and i have been friendsfor over 20 years now and i remember those days where you know, katherine was just on screenfilming every single day and it's, it's heartbreaking when you feel you'retuning up and you're not looking good because the public face is a huge partof what you do. and being in the beauty
industry for a very long time myself and i used to have skin issues as well, the fact that i turn up to work and i was performing skintreatments all day and my skin was looking a lot worse for wear and no goodlighting in the world can hide that when your client is this far from you, you know. so it is devastating for us as well when we have these skin issues. the confidence that you can have from being able to prove their skin is enormous so thank you for sharing that withus as well katherine. and now i'm goingto jump to a few of the questions that we had pre posted before thewebinar. one of them here is this is
from bedroom breathy and this is for you,bill. it says, could it be applied to improvesports performance? you're an ultrarunner, one of thepotentials and limitations of the human body to perform. well there's actually no studies havebeen done officially yet, but i personally have seen tremendousimprovement in my ultra marathon running when i first started taking fauxtelomerase inducers. the... so one truth 818 is going to be working on the skinbut there's a weaker things, natural products that are probably like threehundred times weaker than one truth
818 that you can get nowadays that aresupplements you can swallow. and when i first started taking those i saw my performance in fifty mileraces and hundred mile races which in would be like a hundred, eightykilometers to a hundred and sixty kilometer races improved tremendously. i,you know, i've typically always been the back of the pack runner, i was glad to just finish theselong-distance races. but suddenly right after within three weeks after i startedtaking telomerase inducers to lengthen telomeres or at least lengthen the shortestones, i started seeing my performance get
so well, great that i started finishing inthe top ten, top ten percent sometimes the top 10 overall in my age group.and i'm 64 years old now and i am still slaughtering all the 50 year olds andmany of the 40 year olds in many of my races. so i do believe that it'shelping a lot, but we don't have any real data on it because there really isn't alot of strong telomerase inducers available on the market yet theyactually start doing a study i can tell you in reverse is also true. it turns out that endurance exerciseactually helps keep your telomeres long. so endurance exercise and taking in telomerase inducers is going to be working a
double weight, going to give you twicethe benefits. so yeah i do believe that that is goingto help with sports but we don't have data to support it yet. great. hey, i have a couple questions and more questionshere too but just at this point to you folks who are listening to us and you dohave a question, please just below the video of us just pop your question in there and i'lldo our best to get to it for you.
another one for you, bill, from sample. what would the scientific breakthroughsnec- what are the scientific breakthroughs necessary, i beg your pardon, to movedown the path towards human immortality? huh, you know i'm, i think the most ofscientists in my field know exactly what to do. it's not the breakthroughs thatwe need, it's the funding that we need and that's one of the reasons i'm soglad to see that one truth 818 is providing funding to our research whenever anybody buys a bottle, a certain amount of royalty from that goesdirectly to our research. but it's, what we need to do is research to develop astronger
telomerase inducers and if i was tograph our progress from the beginning, from like nineteen ninety nine to twothousand eight when the global financial crisis hit you can see a pretty linearline of getting stronger and stronger telomerase inducers and i predict that wewould be, something, have something potent enough to actually start showingoverall age reversal. so not just seeing your skin lookyounger and your hair getting better color but you start looking andfeeling young in every way imaginable. i think we're one to three years awayfrom that. and it really isn't a question of any discoveries as much as it isdoing getting the funding to do the work
that we know we need to do. and you knowwe're not the only ones working on trying to cure the aging process andsome other people have some great ideas too which i think will be, you know ithink like the telomeres would probably cover everything but other people areworking on other things too and i they just need the funding too, so it's pretty muchjust funding. ok, i'm just reading on the quick pop uphere from leslie. thank you leslie. says, we used telomerase 818 in combination with which stimulate cell production. in this case is this rapid cellularreproduction increasing the shortening
of the telomeres beyond the capacityof tam 818 to extend telomere life? did you want to take that one, bill?well i could say i don't know the answer to that, again, because we haven't actuallydone that study. we could do that study but again funding is the limitation. so all we'd have to do is grow skin cells in a petri dish in the absence orpresence of epidermal growth factor and in the presence or absence oftam 818 to actually answer that
question. but i personally think that ifepidermal growth factor is something that actually helps make cells leastappear younger i think people should still do it even if the telomeres aregetting shorter because i think we're only talking of one to three yearsaway from having something that would be able to undo anything that might be, that might happen from having short telomeres. so, you know, i always say what's the point of living a long time if you're not living?so if there's something you're doing that makes you feel good or look good but itactually is accelerating your telomere shortening, do it anyway and we'll have afix for it soon. rachael. thanks, bill. and
actually, to leslie, cause i get asked that a lot oftimes on very specific treatment, you know, what do you think about, you know,chemical peels, what do you think about microdermabrasion, all these things thatare actually the whole purpose is to increase cell turnover. and you know in anutshell what we've learned from bill is that cell division equals aging and soif you're speeding up their cell division you're actually speeding upaging. but i mimic what bill is saying is thatif it's making you look good and it's making you feel better about yourself,
you know katherine and i spoke about thatconnection between how you look and how you feel, then i would never tell you tostop performing those treatments or suggest that people stop doing them. butwhat i would say is as an insurance policy you absolutely must be inducingtheir telomerase topically in those cells so that you can be making surethat you balance it out. you know telomerase and cell divisionis a tug-of-war and if you're just having them shorten andshorten and shorten and not going back the other way then you probably willregret it in 10 or 15 years time. but there is the product now and whichwasn't available before which can help
with the tug of war and pull it backthe other way. so if you want to be doing those kindsof treatments i just say you absolutely one hundred percent must be balancingit with a telomerase inducer and one truth 818 is the very strongestin the world. there's actually only one kind ofproduct on the market that sees that they can induce telomerase topically anda local published data shows that one truth 818 is 300 to 800 times strongerthan that. so please be recommending to all of yourclients and to yourself and to be using your one truth
818 serum if you're doing all ofthose procedures. charlene miller says that she just wants to be rubbingone truth all over her body but she can't quite afford to do that. and there's afunny question i do get asked when i'm presenting this sometimes, you know, and people would say i was doing my face and it felt great so obviously now i come down to my neck and now i'm doing my decolletage and everything is firmingand lifting and so i looked a little bit lower and thought, can i keep going, you know, where do istop? now the fact that one truth is a prestige price at the moment, i can'tsay that that's not going to change to be
honest. just to give you an idea when we started it was made with a 50 gram sample and it costs half a million us dollars. that's why it got put in the cupboard anddeemed way too expensive. now luckily for us the intricacy of thetam 818 molecule is so strong that we don't need to be putting a hundred gramsof it into each bottle of skin cream. you know the efficacy that you get from it doesn't need that much. so we're actually kind of lucky that it'son a commercial scale whatsoever considering how expensiveit is. we may be working on a body
cream, there was another questionposted earlier saying what other products can i be expected to see thisin. i can tell you i have been given stability results on a professional useonly gel, so that's for your institutions, your therapist, your place expected to beusing after treatment to help induce that telomerase and heal, speed up thehealing process which inducing telomerase has been proven to do. we also havea spritz which will be coming on the market for the next few months and it'scompletely oil free. we know that there are a lot of people who want to bedoing anti aging treatments but you still have quite oily skin.
now the serum is a really oil richformula. it's full of phospholipids, macadamia oil, jojoba oil. don't get me wrong it's like silk itjust sinks straight into your skin but it is a very oil rich formula and forsome people that is too strong so we're gonna be having that spritz comeout. so for people who want to keep the oil off the skin and for those one truthjunkies out there, you can spritz and then you can use your serum over top aswell, so we've got it all covered. so those are the products that you can lookforward to seeing come soon. now excuse me, i'm just going toquickly... we are answering all of
these questions live. could the application of tam 818directly onto the scalp help encourage hair growth? and that's from dan. we haven't done any study in this. bill,would you know the answer to that? well i have heard, i have heard, i'm getting an echo. i said i haveheard that some people taking some of the supplements have seen hair growthcome back. some of those weaker supplements and but i think it's it'sgoing to be dependent largely on why you are losing hair.
if you're losing hair like, like a malepattern baldness is typically caused by a gene on the x chromosome. and soif, if you're a man and your mother's father was bald, there's a good chancethat you inherited the gene to also be bald. i think that that's unlikely that telomere, lengthening telomere is going to prevent that kind of baldness or growor reverse that kind of baldness. but there's other things that cause baldnessand if it's if it's related to short telomeres and i would anticipate yeah no data yet this is no studies havebeen done but absolutely i would expect to see that hair would come back, but ithink each person has to test it out on
themselves unless they know exactly whythey're bald already. but if they don't know, you know try itbecause if if their bald because the skin cells in their hair, their hairfollicle cells had short telomeres then there's a good chance that they canbring their hair back i would imagine, i can't say that for certain. cool and what i can say to that too is when we first heard the tam 818 we wereplaying with the formulations with old friends and we were asking them to rub theserum on their, on their heads for us. but it was so difficult to kind ofmeasure any response there. they weren't really consistent on how theyused it, and there was actually no hair
there and they have gone bald quiteyoung. so as bill was saying it may not be age related at all. but interms of a product to use because nobody wants to be putting it, rubbing aserum in to the roots of their hair, when the oil freespiritz comes out that would be a great product to use to simply be parting your hair where it's thinning and be spraying that on because it's gonna be a lot morepleasing to use than rubbing, rubbing a serum into the roots of your hair. i have another question here. can 818 be ingested? now we don't know the answer to that question i'mgonna see if bill wants to add anything more.
but i do have a very funny littleanecdote, i was having a meeting with someone a couple months ago, adoctor in america, not bill. and he said, "by the way, you know yourproduct tastes awful." i said, "um i'm sorry what product?", thinking he had confused me for someone who had an ingestible product. he goes, "your serum, it tastes really bad but i've beentrying it anyway." i was quite surprised by that, but bill, what are yourthoughts about ingesting tam 818 in the future there? well as you said we have not tested thatfor ingestion yet and we would have to
do a lot of safety studies and stufflike that first. but it's you know it... right now, huh we don't know. but i would imaginethat if it does survive the stomach and get into the blood it would offer tremendous benefits. butagain i do not recommend anybody try that. don't, especially when it's in the serum because it might actually make you quite sick. but it is, right now its designed to work on skin and i have heard that there are studies being done, maybe rachaelcould validate that. there's
talks about doing studies to see if it can be ingested. so there's talk of doing clinical studiesbut i don't think they're underway yet. rachael, are they underway yet? well, well kind of. so when bill phrased that question to meit's because chase life extension foundation as we mentioned tested the license for tam 818 and we're really pledged ourselves in a partnership with sierra sciences totake over the commercialization of tam 818 at any marketing of it. so yes ofcourse, we're really interested to see if tam 818 could be the beginning of an oral supplement, which cures
aging in an entire body. so we've been very very early stages ofthat. you can hear this hot off the press just two days ago we took somecontrolled blood to the auckland university to have that tested and they're currentlyseeing if their machinery and equipment can detect tam 818 inside thebloodstream. but like i said this is really very very early days, butwe would like to think that tam 818 is proving to induce telomerase in ahuman body and the blood that within the next two to three years we'll be able tohave and make for a product which has the exact same thing as tam 818and that strength as well because
currently as bill mentioned the naturaltelomerase inducers are very very mild and nowhere near 16-percent. so my company chase life extension foundation in conjunction with sierrasciences is looking to do that and it's very very exciting. so stay posted we of course will let youknow if we have any further developments there. but that really is theway that this technology is going. hey i have another question here, thankyou for all the questions everybody, from ena in melbourne, how does one truthwork on diminishing hyperpigmentation? ena i can't explain the pathways it takes to do that because we
simply haven't been able to look at that in depth, but what we do know is that it does work.and my easiest way of explaining that is when you are using one truth 818topically it induces telomerase in the cells because it does get into the cells. you express telomerase and your cell becomes younger. now if you're getting a younger skin, a younger skin doesn't scar like an older skin, it doesn't express melanin likean older skin, it does express collagen and elastin it makes more hyaluronic acid. so by making yourself younger, there's something more your skin
is getting. so you're literally are justreducing and undoing all of that pigmentation, and that's a big thing thatwe saw through the clinical medical trials in italy and also right in frontof our very eyes in the new zealand trials. and obviously we get a lot offeedback from people all over the world to be using one truth who had reallydiminished their pigmentation. interestingly sometimes it's hormonalpigmentation as well, particularly chloasma caused predominantly by women having babies, it's hormonal. so in my eyes therewas really no reason for that to be reversed by making the cells youngerbecause if you hadn't had a baby
you wouldn't have that pigmentation. thatwasn't particularly age-related so the way to explain it i think it's justthat your cell is behaving like a younger cell which wouldn't haveexpressed that melanin, would you agree with that, bill? i've got absolutely no experience inthat whatsoever but what you just described sounds like exactly what i would have speculated, we will, we'll find out. i actually hadn'theard until just now that it actually does work on hyperpigmentation. yeah very, very well and you know,it's often it's to do with the sun, it's to do
with hormones and one truth 818 isreversing that pigmentation as well. and then that's my speculation of why it works. i can't say that in a scientific sense because we haven't followed thatchemical pathway to find that exact why, for reducing pigmentation but itdefinitely is. thank you from ike chronroguess, when you get a result ofsixteen percent, is this number in contrast to the natural rate of agingand is the number concentration dependent? ok so that, it's a question for me? yes sorry about the misunderstanding. next part of the question, they also asked
if it's different substances havedifferent biological pathways inducing telomerase. i can answer all three of thosequestions. ok, so as rachael responded earlier, referred to earliertelomere shortening and lengthening is like a tug-of-war. and if you imagine you've gota thousand people pulling to shorten, to cause the telomeres get shorter, and youbalance that with 16 people pulling it to get longer, you're actually still having telomereshortening because the people pulling are losing the tug of war but atleast they're slowing down those sixteen
percent , those 100 people. so you got 16 pulling to lengthen and 100pulling to shorten, you're still losing but you're losing it a shorter rate. we've done a lot of studies using genetherapy to be able to quantitate how much telomerase is needed to actuallycause the tug of war to be a tie. and so we call that so when we find it a drug or let's sayif we find a drug or natural product that induced that much telomerasewe'd give that score, we'd give that chemical score of 100. so that means thetug of war is a tie. so it's not
not so much relative to aging as much it is to how much telomerase are reproducingrelative to how much is needed to cause that tug of war to be a tie. and so we'reat sixteen percent. the second part of that question was is itconcentration-dependent. it is concentration-dependent but when we saysixteen percent that's the maximum. okay so every drug whenever you test anykind of drug in any kind of assay you'll find when you graph it you'll find thatit increases linearly and then starts to level off and then you actually find itto drop. ok that's true, that's a dose curve youfind for every kind of chemical you ever
tested in any kind of assay. so what we dowhen we look at this dose curve we find out where it starts to level off. and in the case of, so we find what kind,what kind of dose causes that, and it let it, with the tam 818 or c0314818 it levels off at about sixteen percentof the height that we'd like it to be and it doesn't get any higher when you go to higher concentration. so the amount that's inthe one truth 818 is actually just a little bit higher than that. sousing more of it isn't probably going to give you higher telomerase activity. using itmore often
might keep that telomerase activity at thehigh levels that it is. so i wouldn't, i wouldn't try to start putting a lot of it on, i think rachael said that in jestearlier, but using it more often might has a, could have a chance ofactually keeping the telomerase levels high. for the last part of the questionessentially is, ok so we have, as i mentioned we had tested over 400,000different chemicals and our strongest one was c0314818. but we found ninehundred other different chemicals too and we imagine that they do work bydifferent pathways. we could take the 900 chemicals and we could find just lookingat their structure that they represent
37 different families of chemicals. andso we have these nine hundred all worked into these 37 count families. one of the things that we'd like to do is we'd like to try mixing them to seeif they actually will give us a synergistic activity or like even additive activity, although again that's a super expensive experiment to do andwe have to wait for the funding to come in. but yeah, we do hope that that'sthe case in which case we can get a lot of higher levels of telomerase activityin one truth 818, but then it would probably called one truth 818 and 1079so it would have a different name, but it
would, we just have to see, we won'tknow until we try. ok. this is all brand new science, everybody's got to be aware of that. anybody using one truth 818 is on the cusp of absolutely brand new science and soyou're actually participating in a study when you do it because we want to hearfrom everybody how well it's working. alright thanks. rachael. yeah and the great thing is too, youknow for my little old company down here in new zealand, the land of the hobbitsas everyone likes to call us, the studies that that we could mesh into the latest are the most
extensive studies in a ton of topicaltelomerase induction ever, you know. so it's really great that we've done that and that is in our product and that's what one truth 818 is. what bill was sayingbefore leads into micro drug is this question, which is have we triedphytosome technology to increase the score of herbal extracts and its complexation with phospholipids. now like the liposomal delivery system that we actually use for the tam 818 that we modified from the c0341818 is actually a phospholipid base soit's interesting that you should ask that question.
we didn't find that it increasedthe sixteen percent score but it definitely was the same score but with a better delivery system doubly. it's really hard to test whatthe score is once it gets into a real human being. i mean bill has access to skin cells in apetri dish, but once it actually inside the dermis, there aren't manypeople who want to have their faces hole punched to then donate those skin punctures to someone to be doing any test with them. and as billmentioned too it's very, very expensive to do that, do that kind of thing.
we rather work, doing thetesting that we have done, we do create revenue and income on one truth 818, it goes straight to bill for researchinto further anti-aging. so whether or not we decide to backtracka little bit and keep on testing more on the skin or whether bill drivesforward and heads to making those stronger telomerase inducers, that's probably the way we're going to go. just to keep on looking for the strongest telomerase inducers like we mentioned before, eventually leading to what will be a cure for aging for humans. now i'vegot it looks like we may have been able
to serve all of those questions nowwhich is fantastic but i have one more question which i've saved for the last.i had, bill''s talked about funding, i've talked about the, giving you abit of an insight into the test that my company's about to do with bill as well,but lisa morgan says how far away are you from finding a way to reverseaging, bill. it's again, i did address it a little bit, it's more funding than it is time. if the global financial crisis of2008 hadn't hit we'd already see betty white
walking out onstage looking 24 years oldagain, in my opinion. but the global financial crisis has shut down research not just mine, but everybody iknow because research is actually quite expensive. so when we get the fundingthat we need to actually continue our research at the level we were doingbefore two thousand eight i would say it, we're one two three yearsaway from doing that. and i want to caution that i don't believe that it isgoing to be the only thing that needs to be done but i do believe thatlengthening or find a way to lengthen telomeres is something that absolutelyhas to be done because there's no
question about the fact in thescientific literature that that telomere shortening does limit the lifespan ofour cells and therefore us. and so if we can find a way to overcome that, thatwill allow us to possibly live longer. i don't know how long, i wouldn't besurprised if we live to be a hundred and fifty, 250, i don't know. but you know it's,but i do believe that we are going to run into other obstacles like oxidativestress and mitochondrial dysfunction that are also going to be affecting usat a probably slower rate than the telomeres do but we have to solve those problems too.and so i just think that you know if i can get another 30 years added to mylife just from telomeres and that's
going to give me another 30 years thattry to figure out how to solve some of those other problems. so we might betrying to figure out ways of actually lengthen lifespan in chunks movingforward and forward but as long as we can move at a faster rate than we'reaging we should be able to stay ahead of that curve and all of us to be able tolive very long and healthy lives beginning in about one year after we getthe funding and i'm looking forward to one truth 818 sales providing us that funding. yeah and just on it bill, you know, on aon a business level and a personal level i'm so proud
to give, and we make it very public, wegive forty percent of our revenue, that's not profit but of our revenue from thesales of one truth straight back to sierra sciences to go toward the research forthe cure for aging. so let me just say at this point if you would like to bestocking one truth in your anti-aging skin care clinic or medical facility andand be helping to advance this movement towards curing aging and all age-relateddiseases if you'd like to say good bye to all of them, there is a big button on the screen, a big purple button that says learn how here. so we would love it if you would want to join the handful ofstockists that we already have in australia.
click the learn how here button andall over the world but i know predominantly there are many australiansof this call today and we'll put you through. we've got a great offer toall of you business owners who are listening today and the offer isactually for area exclusivity. now if you sign with us today we can guarantee you that you'll be the only stockist in your area to have one truth 818 serum with dr. bill andrews' tam 818 technology. so big purple button says learn how here. atthis point i would really like to thank everybody for joining us on this call. we love the questions because theinterest in the science is so phenomenal.
as bill explained perfectly, if you areinvolved with telomere biology and with one truth 818, you are at theforefront of groundbreaking science and i congratulate you for being interestedenough in your profession and into your lives to be here to hear about this. so thank you very very much to dr. billandrews for your knowledge and your participation today we really appreciatethat. and also a big thank you to my dear friend katherine kennard using one truth 818 for being here to share your storywith us today and also for sharing your beautiful face with us, when it comesto putting 818 out there on the map.
my pleasure absolutely. thank you now forthose of you who are wanting more you had many emails from the one truth 818 australia team, you've gottheir contact details and their phone number, so feel free to contact them. if there are any more questions they actually will file them throughpersonally to myself or bill. so we're always open and available totalk through to you. if there's one thing i know about bill, he loves nothing more than talking about telomere biology,is that right? yes that's right. in fact i loveanswering questions so don't hesitate to
send me any and all questions. alright, thank you. so thank you onceagain everyone for joining us and we look forward to the next time. everyone have a great day. bye. bye bye.
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